Multivariate Control of Transcript to Protein Variability in Single Mammalian Cells
نویسندگان
چکیده
منابع مشابه
Control of Transcript Variability in Single Mammalian Cells
A central question in biology is whether variability between genetically identical cells exposed to the same culture conditions is largely stochastic or deterministic. Using image-based transcriptomics in millions of single human cells, we find that while variability of cytoplasmic transcript abundance is large, it is for most genes minimally stochastic and can be predicted with multivariate mo...
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Gene expression levels vary greatly within similar cells, even within clonal cell populations [1]. These spontaneous expression differences underlie cell fate diversity in both differentiation and disease [2]. The mechanisms responsible for generating expression variability are poorly understood. Using single-cell transcriptomics, we show that transcript variability emerging during Dictyosteliu...
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The performance of geostatistical and spatial interpolation techniques for estimation of spatial variability of heavy metals and water quality mapping of groundwater resources in Ramiyan district (Golestan province- Iran) were investigated. 24 spring/well water samples were collected and the concentration of heavy metals (Ni, Co, Pb, Cd and Cu) was determined using Differential Pulse Polarograp...
متن کاملFrom Transcript to Protein
is currently being directed toward identifying the protein components of spliceosomes, determining how they in-Meyerhofstrasse 1 Postfach 102209 teract with pre-mRNA and with each other during the splicing reaction, and analyzing how these interactions D69117 Heidelberg Germany are regulated. tut Pasteur, Paris) reported studies on how 5Ј splice sites and branch sites in budding yeast pre-mRNAs...
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ژورنال
عنوان ژورنال: Cell Systems
سال: 2018
ISSN: 2405-4712
DOI: 10.1016/j.cels.2018.09.001